The Relationship Between Serum Vitamin D Levels and Pain Severity in Children with Migraine

INTRODUCTION: Migraine is a primary episodic headache disorder accompanied by neurological, gastrointestinal and autonomic changes. The aim of this study is to compare vitamin D levels with headache severity in patients with migraine.
METHODS: A total of 108 children diagnosed with migraine were evaluated. We measured Vitamin D levels and 25-hydroxy vitamin D3 with the enzyme-linked immunosorbent assay (ELISA) method. Serum vitamin D was defined as <12 ng / ml insufficiency. Serum vitamin D was defined as deficiency in those with 12 - 30 ng / ml. Serum vitamin D was defined as normal in those with> 30 ng / ml. The severity of the headache was assessed according to the Migraine Disability Assessment Score (MIDAS).
RESULTS: The mean serum 25-hydroxy vitamin D3 levels of migraine patients was 16.6 ± 5.9 ng/ml. As the level of Vitamin D decreased, so the severity of the headache increased, with a higher MIDAS score (p<0.05). No relationship was determined between the MIDAS score and levels of calcium, phosphorus and alkaline phosphatase (p>0.05).
DISCUSSION AND CONCLUSION: When vitamin D levels are reduced in children with migraine, this can cause an increase in the severity of headache.