ISSN: 2718-0085
Volume: 2 Issue: 02 Year: 2021
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Langerhans Cell Histiocytosis with Isolated Central Diabetes Insipidus, Low Grade Fever and Sellar Erosion [TIP]
TIP. 2021; 2(2): 104-108 | DOI: 10.5222/TP.2021.86580

Langerhans Cell Histiocytosis with Isolated Central Diabetes Insipidus, Low Grade Fever and Sellar Erosion

Iclal Okur1, Hasan Ari1, Semra Çetinkaya1, Betul Emine Derinkuyu2, Gizem Çağlar3, Hasibe Gökçe Çınar2, Sule Yeşil4, Senay Savaş Erdeve1
1University Of Health Sciences Turkey, Dr. Sami Ulus Obtetrics And Gynecology, Children’s Health And Disease Training And Research Hospital, Department Of Pediatric Endocrinology, Ankara, Turkey
2University Of Health Sciences Turkey, Dr. Sami Ulus Obtetrics And Gynecology, Children’s Health And Disease Training And Research Hospital, Department Of Pediatric Radiology, Ankara, Turkey
3University Of Health Sciences Turkey, Dr. Sami Ulus Obtetrics And Gynecology, Children’s Health And Disease Training And Research Hospital, Department Of Pediatrics, Ankara, Turkey
4University Of Health Sciences Turkey, Dr. Sami Ulus Obtetrics And Gynecology, Children’s Health And Disease Training And Research Hospital, Department Of Pediatric Oncology, Ankara, Turkey

Langerhans cell histiocytosis (LCH) is a rare disease of the monocyte-macrophage system. Although it is known that bone involvement is seen very frequently in cases with LCH, our case is the first case with a lytic-destructive lesion in the bone structure forming sella turcica.
A 4-year-old, 5-month-old male patient who applied to our outpatient clinic was diagnosed with Langerhans cell histiocytosis in further examination after the diagnosis of central diabetes insipidus (CDI) was made. On cranial magnetic resonance imaging (MRI), widespread lytic-destructive bone lesions were observed in the bone structure forming the sella (sphenoid bone), sellar destruction not previously described in the literature.
Sellar erosion has not been reported before in cases diagnosed with LCH in the literature. The presence of low-grade fever in a patient presenting with isolated CDI is a warning sign for the diagnosis of LCH.

Keywords: Bone lesion, Central diabetes insipidus, Children, Langerhans cell histiocytosis, Sellar erosion

Iclal Okur, Hasan Ari, Semra Çetinkaya, Betul Emine Derinkuyu, Gizem Çağlar, Hasibe Gökçe Çınar, Sule Yeşil, Senay Savaş Erdeve. Langerhans Cell Histiocytosis with Isolated Central Diabetes Insipidus, Low Grade Fever and Sellar Erosion. TIP. 2021; 2(2): 104-108

Corresponding Author: Iclal Okur, Türkiye
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