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Volume: 3 Issue: 01 Year: 2022
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Is Plasma C-Type Natriuretic Peptide Level Suitable for Diagnosing and Typing Skeletal Dysplasia? [TP]
TP. 2022; 3(1): 18-23 | DOI: 10.4274/TP.2022.95866

Is Plasma C-Type Natriuretic Peptide Level Suitable for Diagnosing and Typing Skeletal Dysplasia?

Sirmen Kızılcan Çetin1, Damla Gökşen2, Samim Özen2, Hüdaver Alper3, Esra Işık4, Su Özgür5, Şükran Darcan2
1Ege University Faculty of Medicine, Department of Pediatrics, İzmir, Turkey
2Ege University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, Turkey
3Ege University Faculty of Medicine, Department of Radiology, İzmir, Turkey
4Ege University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Genetics, İzmir, Turkey
5Ege University Faculty of Medicine, Department of Biostatistics and Medical Informatics, İzmir, Turkey

Objective: Skeletal dysplasia is a heterogeneous group of diseases that lead to abnormal enchondral ossification and typing of the disease is quite complex. C-type natriuretic peptide (CNP), one of the members of the natriuretic peptide family, has been implicated in bone development, and CNP levels are high in some types of skeletal dysplasia. The aim of this study was to evaluate the use of CNP as a marker for skeletal dysplasia types and to investigate its role in typing.
Methods: Thirty-seven patients aged six months to 18 years [26 (70.3%) girls] were included in this cross-sectional study from among 75 skeletal dysplasia patients. All subjects were physically examined; anthropometric measurements were obtained, and bone surveys were evaluated. ELISA was used to assess CNP plasma levels. Forty-nine healthy children aged six months to 18 years [24 girls (49%)] comprised the control group.
Results: The CNP concentration of the patient group (n=37) was 1.31±1.40 ng/mL which was similar to the control group (n=49) at 1.04±1.40 ng/mL (p=0.207). However, the CNP concentration of patients with achondroplasia (n=17) was significantly higher (1.79±1.64 ng/mL) than the control group (p=0.032).
Conclusion: Our study contributes evidence concerning CNP values of both healthy children and children with skeletal dysplasia. Compared with healthy children, those with achondroplasia have elevated plasma levels of CNP. Further larger studies are necessary to assess the use CNP as a marker for the diagnosis and typing of skeletal dysplasia.

Keywords: Achondroplasia, c-type natriuretic peptide, short stature, skeletal dysplasia

Sirmen Kızılcan Çetin, Damla Gökşen, Samim Özen, Hüdaver Alper, Esra Işık, Su Özgür, Şükran Darcan. Is Plasma C-Type Natriuretic Peptide Level Suitable for Diagnosing and Typing Skeletal Dysplasia?. TP. 2022; 3(1): 18-23

Corresponding Author: Sirmen Kızılcan Çetin, Türkiye
Manuscript Language: English
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