Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by premature aging resulting from an autosomal mutation in the LMNA gene. This article presents a groundbreaking instance of the first female monozygotic twins affected by HGPS, originating from Brazil, highlighting the exceptional nature of this case.

Keywords: Hutchinson-Gilford Progeria syndrome, Monozygotic Twins, female, Progeria

Copyright and license

How to cite

Carlos Reis-Filho N, Aguiar TKPP, Ramos DLS, Müller BMM, Oliveira IS, Cerni FA, et al. Unprecedented report: First female monozygotic twins as carriers of Hutchinson-Gilford progeria syndrome. Trends in Pediatrics. 2024;5(2):38-42. https://doi.org/10.59213/TP.2024.115


  1. Ahmed MS, Ikram S, Bibi N, Mir A. Hutchinson-Gilford Progeria Syndrome: A Premature Aging Disease. Mol Neurobiol. 2018;55:4417-27. https://doi.org/10.1007/s12035-017-0610-7
  2. Lamis A, Siddiqui SW, Ashok T, Patni N, Fatima M, Aneef AN. Hutchinson-Gilford Progeria Syndrome: A Literature Review. Cureus. 2022;14:e28629. https://doi.org/10.7759/cureus.28629
  3. Lima LL, Ribas CBR, Pereira PMR, Eiras JC, Ribas CBR, Schettini RA. Do you know this syndrome? An Bras Dermatol. 2011;86:165-6. https://doi.org/10.1590/s0365-05962011000100031
  4. The Progeria Research Foundation. 2023. Available at: https://www.progeriaresearch.org (Accessed on June 15, 2023).
  5. Viégas J, Souza PL, Salzano FM. Progeria in twins. J Med Genet. 1974;11:384-6. https://doi.org/10.1136/jmg.11.4.384
  6. Dhillon S. Lonafarnib: First Approval. Drugs. 2021;81:283-9. https://doi.org/10.1007/s40265-020-01464-z
  7. Eriksson M, Brown WT, Gordon LB, et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 2003;423:293-8. https://doi.org/10.1038/nature01629
  8. Kamenisch Y, Berneburg M. Progeroid syndromes and UV-induced oxidative DNA damage. J Investig Dermatol Symp Proc. 2009;14:8-14. https://doi.org/10.1038/jidsymp.2009.6
  9. Misteli T. Farnesyltransferase inhibition in HGPS. Cell. 2021;184:293. https://doi.org/10.1016/j.cell.2020.12.029
  10. Strandgren C, Revêchon G, Sola-Carvajal A, Eriksson M. Emerging candidate treatment strategies for Hutchinson-Gilford progeria syndrome. Biochem Soc Trans. 2017;45:1279-93. https://doi.org/10.1042/BST20170141
  11. Solan TD, Lindow SW. Mercury exposure in pregnancy: a review. J Perinat Med. 2014;42:725-9. https://doi.org/10.1515/jpm-2013-0349
  12. Khan F, Momtaz S, Abdollahi M. The relationship between mercury exposure and epigenetic alterations regarding human health, risk assessment and diagnostic strategies. J Trace Elem Med Biol. 2019;52:37-47. https://doi.org/10.1016/j.jtemb.2018.11.006