Abstract

Calcium channel blockers (CCBs’) and angiotensin receptor blockers (ARBs’) are widely used in clinical practice and are easily available. Intoxication with these drugs results in life-threatening deep vasoplegic shock, making them particularly dangerous, especially for children. Here, we report two patients who ingested amlodipine and irbesartan for suicidal attempts and were unresponsive to all conventional treatments. They were placed on venoarterial extracorporeal membrane oxygenation (VA-ECMO) and hemodynamically stable immediately after extracorporeal life support (ECLS). Patients were successfully decannulated and extubated. CCB and ARB poisoning that are resistant to medical therapy can be treated by ECLS successfully.

Keywords: Amlodipine poisoning, irbesartan poisoning, vasoplegic shock, extracorporeal life support, children

Copyright and license

Copyright © 2024 The author(s). This is an open-access article published by Aydın Pediatric Society under the terms of the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

1.
Koç G, Ersayoğlu İ, Cebeci K, Çınarlı S, Yazıcı Özkaya P, Tuncer ON, et al. Life-threatening amlodipine and irbesartan poisoning in two adolescents: Extracorporeal life support is life-saving. Trends in Pediatrics. 2024;5(2):48-51. https://doi.org/10.59213/TP.2024.134

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