Calcium channel blockers (CCBs’) and angiotensin receptor blockers (ARBs’) are widely used in clinical practice and are easily available. Intoxication with these drugs results in life-threatening deep vasoplegic shock, making them particularly dangerous, especially for children. Here, we report two patients who ingested amlodipine and irbesartan for suicidal attempts and were unresponsive to all conventional treatments. They were placed on venoarterial extracorporeal membrane oxygenation (VA-ECMO) and hemodynamically stable immediately after extracorporeal life support (ECLS). Patients were successfully decannulated and extubated. CCB and ARB poisoning that are resistant to medical therapy can be treated by ECLS successfully.

Keywords: Amlodipine poisoning, irbesartan poisoning, vasoplegic shock, extracorporeal life support, children

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Koç G, Ersayoğlu İ, Cebeci K, Çınarlı S, Yazıcı Özkaya P, Tuncer ON, et al. Life-threatening amlodipine and irbesartan poisoning in two adolescents: Extracorporeal life support is life-saving. Trends in Pediatrics. 2024;5(2):48-51. https://doi.org/10.59213/TP.2024.134


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