Abstract

Objective: The purpose of this study was to assess the serum anti-Mullerian hormone (AMH) levels and related factors in overweight and obese girls during their prepubertal, pu-bertal, and post-menarcheal periods.

Method: Anthropometric measurements, physical examination features, laboratory findings, and serum AMH levels were evaluated in girls with overweight and obesity admitted be-tween March and April 2021 in the Pediatric Endocrinology Clinic at Erciyes University Faculty of Medicine.

Results: Serum AMH levels were evaluated in a total of 40 girls: 12 (30%) prepubertal, 12 (30%) pubertal, and 16 (40%) post-menarcheal. Their ages were 7.7 (±1.7), 10.3 (±2.1), and 15.4 (±1.8) years, and their serum AMH measurements were 2.4 (±2.4), 2.1 (±1.1), and 4.6 (±3.7) ng/mL, respectively. The serum AMH levels between prepubertal and pubertal girls and post-menarcheal girls were significantly different (p=0.020). There was no significant difference when compared to normal AMH levels for their age (p=0.722).

In the age-adjusted correlation analysis of the patients, no significant relationship was found between AMH levels and anthropometric measurements (height, weight, weight-SD, BMI, BMI-SD, neck circumference-SD, mid-upper arm circumference-SD, waist circumference-SD, waist-to-height ratio, and waist-to-hip ratio). A positive correlation was found only in height-SD (r=0.334, p=0.038).

Conclusion: The study found that the serum AMH levels of girls with overweight and obesi-ty increased moderately during the prepubertal period, specifically several years preceding puberty, slightly decreased during the onset of puberty, and significantly increased during the post-menarcheal period, like healthy girls.

Keywords: Anti-Mullerian hormone, body mass index, body measurements, obesity, puber-ty

Copyright and license

Copyright © 2024 The author(s). This is an open-access article published by Aydın Pediatric Society under the terms of the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

1.
Sarıkaya E, Çiçek D, Kara L, Suman Gök E, Berber U, Gül Şiraz Ü, et al. The relationship between serum anti-mullerian hormone levels and puberty in girls with obesity. Trends in Pediatrics. 2024;5(3):79-84. https://doi.org/10.59213/TP.2024.149

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